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Down's Syndrome

What is Down syndrome?

Down syndrome is a genetic condition that results when there is an extra copy of a specific chromosome, chromosome 21.
It is not an illness but a term that describes the features resulting from this change.
The extra chromosome can affect the physical features, intellect, and overall development of an individual.
It also increases the likelihood of some health problems.

Causes

Down syndrome happens when there is an extra copy of genetic material on all or part of the 21st chromosome.
Every cell in the body contains genes that are grouped along chromosomes in the cell's nucleus. There are normally 46 chromosomes in each cell, 23 inherited from the mother and 23 from the father.
When some or all of a person's cells have an extra full, or partial, copy of chromosome 21, the result is Down syndrome.

Characteristics

People with Down syndrome often have distinct physical features, unique health issues, and variability in cognitive development.

Physical features

Physical characteristics include:
  • eyes that have an upward slant, oblique fissures, epicanthic skin folds on the inner corner, and white spots on the iris
  • low muscle tone
  • small stature and short neck
  • flat nasal bridge
  • single, deep creases across the center of the palm
  • protruding tongue
  • large space between large and second toe
  • a single flexion furrow of the fifth finger

Developmental delays

Individuals with Down syndrome usually have cognitive development profiles that suggest mild to moderate intellectual disability. However, cognitive development and intellectual ability are highly variable.
Children with Down syndrome often reach developmental milestones later than their peers.
There may be a delay in acquiring speech. A child may need speech therapy to help them gain expressive language.
Fine motor skills may also be delayed. They can take time to develop after gross motor skills have been acquired.

On average, a child with Down syndrome will:
  • sit at 11 months
  • crawl at 17 months
  • walk at 26 months
There may also be problems with attention, a tendency to make poor judgments, and impulsive behavior.
However, people with Down syndrome can attend school and become active, working members of the community.

Health issues

Sometimes, there are general health problems that can affect any organ system or bodily function. Around half of all people with Down syndrome have a congenital heart defect.

There may also be a higher risk of:
  • respiratory problems
  • hearing difficulties
  • Alzheimer's disease
  • Childhood leukemia
  • epilepsy
  • thyroid conditions
However, there also appears to be a lower risk of hardening of the arteries, diabetic retinopathy, and most kinds of cancer.

Diagnosis

Women with a higher chance of having a child with Down syndrome may receive screening and diagnostic tests.
Screening tests can estimate the probability of Down syndrome being present. Some diagnostic tests can definitively tell whether the fetus has the condition.

Screening tests

Women aged 30 to 35 years or older may receive genetic screening during pregnancy because the risk of having a child with Down syndrome increases as women age.

Screening tests include:
  • Nuchal translucency testing: At 11 to 14 weeks, an ultrasound can measure the clear space in folds of tissue behind the neck of a developing baby.
  • Triple screen or quadruple screen: At 15 to 18 weeks, this measures the quantities of various substances in the mother's blood.
  • Integrated screen: This combines the results of first-trimester blood tests and screening tests, with or without nuchal translucency, with second-trimester quadruple screening results.
  • Cell-free DNA: A blood test that analyzes fetal DNA found in the maternal blood.
  • Genetic ultrasound: At 18 to 20 weeks, a detailed ultrasound is combined with blood test results.
Screening is a cost-effective and less invasive way to determine if more invasive diagnostic tests are needed. However, unlike diagnostic tests, they cannot confirm whether Down syndrome is present.

Diagnostic tests

Diagnostic tests are more accurate in detecting Down syndrome and other problems. They are usually performed inside the uterus, and they increase the risk of miscarriage, fetal injury, or preterm labor.

Diagnostic tests include:
  • Chorionic villus sampling: At 8 to 12 weeks, a tiny sample of placenta is obtained for analysis, using a needle inserted into the cervix or the abdomen.
  • Amniocentesis: At 15 to 20 weeks, a small amount of amniotic fluid is obtained for analysis, using a needle inserted into the abdomen.
  • Percutaneous umbilical blood sampling: After 20 weeks, a small sample of blood is taken from the umbilical cord for analysis, using a needle inserted into the abdomen.
Down syndrome can also be diagnosed after a baby is born by inspecting the infant's physical characteristics as well as blood and tissue.

Treatment

There is no specific treatment for Down syndrome.
People with the syndrome will receive care for health problems, just as other people do. However, additional health screening for common problems may be recommended.
Early intervention can help the individual maximize their potential and prepare them to take an active role in the community.
Apart from physicians, special educators, speech therapists, occupational therapists, physical therapists, and social workers can all help. The National Institute for Child Health and Human Development (NICHHD) urge all participants to provide stimulation and encouragement.
Children who have specific difficulties with learning and development may be eligible for educational support, either in a mainstream or specialized school. In recent years, the tendency has increasingly been to attend mainstream schools, often with additional support to help them integrate and progress.
Some children will have an Individualized Education Plan (IEP), supported by various specialists.

Types

The most common form of Down syndrome is known as trisomy 21, a condition where individuals have 47 chromosomes in each cell instead of 46.
Trisomy 21 is caused by an error in cell division called nondisjunction. This leaves a sperm or egg cell with an extra copy of chromosome 21 before or at conception. This variant accounts for 95 percent of Down syndrome cases.
The remaining 5 percent of Down syndrome cases are due to conditions called mosaicism and translocation.
Mosaic Down syndrome results when some cells in the body are normal while others have Trisomy 21.
Robertsonian translocation occurs when part of chromosome 21 breaks off during cell division and attaches to another chromosome, usually chromosome 14. The presence of this extra part of chromosome 21 causes some Down syndrome characteristics.
A person with a translocation does not have any special physical features, but they are more likely to have a child with an extra 21st chromosome.<

Outlook

A person with Down syndrome will be able to do many of the things that other people do. Children may take longer to acquire skills such as walking and talking, but with stimulation, they can acquire key life skills and attend school and, in some cases, college.
Depending on how the syndrome affects the individual, it is often possible for someone to work and to live semi-independently with Down syndrome.
Like anyone else, people with Down syndrome need friendships and relationships. Some will live with a partner or get married, and have an independent life. However, it is worth bearing in mind that if one partner has Down syndrome, there is a 30 to 50 percent chance that any children will too.
Average life expectancy is around 60 years, and many people with Down syndrome now live into their 70s.
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